MCP-Server für Bioinformatik-Daten — Gene, Proteine, PubMed-Literatur, Varianten und Sequenzen via NCBI & UniProt
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# bioinformatics-mcp-server MCP-Server für Bioinformatik- und Life-Science-Daten. Gibt AI-Agents Zugriff auf NCBI Gene, UniProt, PubMed und ClinVar — komplett kostenlos ohne API-Key. ## Tools | Tool | Beschreibung | |------|-------------| | `search_genes` | Gen-Suche in NCBI Gene Database (Symbol, Name, Funktion) | | `get_gene_details` | Detailinfos zu einem Gen via NCBI Gene ID | | `search_clinvar_variants` | Klinische Varianten/Mutationen via NCBI ClinVar | | `get_taxonomy` | Taxonomische Klassifikation via NCBI Taxonomy | | `search_proteins` | Protein-Suche in UniProt | | `get_protein_details` | Protein-Details via UniProt Accession | | `get_ncbi_sequence` | DNA/Protein-Sequenzen aus NCBI (FASTA/GenBank) | | `search_pubmed` | Literatur-Suche in PubMed | | `get_pubmed_abstract` | Vollständiger Abstract eines PubMed-Artikels | | `get_pubmed_citations` | Artikel die eine Publikation zitieren | ## Installation ```bash pip install bioinformatics-mcp-server ``` ## Konfiguration (Claude Desktop) ```json { "mcpServers": { "bioinformatics": { "command": "bioinformatics-server" } } } ``` ## Beispiele ``` # Gen-Suche search_genes("BRCA1", organism="human") search_genes("p53", organism="mouse") # Klinische Varianten search_clinvar_variants("CFTR", significance="pathogenic") # Protein-Lookup search_proteins("insulin receptor", organism="human") get_protein_details("P06213") # DNA-Sequenz abrufen get_ncbi_sequence("NM_007294", database="nucleotide") # Literatur search_pubmed("CRISPR gene therapy cancer 2025", max_results=5) get_pubmed_abstract("33461210") ``` ## APIs - **NCBI E-utilities** — Gene, ClinVar, Taxonomy, PubMed, Sequenzen (kostenlos, 3 req/s) - **UniProt REST API** — Proteine, Sequenzen, Funktionen (kostenlos, unbegrenzt) Kein API-Key erforderlich. ## Lizenz MIT
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