Every change Wellknown observed on this MCP server, newest first, with what it was before and what it became. Tool-surface changes carry the definition diff. Nothing here is edited after the fact.
Changed the definition of "predict_inputs", "similar_drugs" and "target_clint"
⟨30 unchanged words⟩ ,"type":"number"},"smiles":{"description":"Structure as SMILES.","maxLength":2000,"title":"Smiles","type" ⟨7 unchanged words⟩
Most similarNearest reference drugs to a SMILES (Tanimoto, Morgan radius 2), each withobservedmeasured human plasma CL andIVIVE-predictedtheclearance:CL IVIVE predicted from its measured inputs. Use it to judge how far to trust calc_clhep for this chemotype: if IVIVEfaredmissed onthisthekindneighbours,ofexpectstructure.it to miss here. Returns neighbours only, not a prediction for the query.
⟨7 unchanged words⟩ for a compound to reach a target plasmaclearance.clearance (mL/min/kg): calc_clhep run backwards, e.g. to set a CLint cut-off for a screening cascade. Needs fu,mic and fu,p; refuses a target at or above the liver blood flow ceiling and returns that ceiling. Uncorrected IVIVE, so no error band.
{"properties":{"assay_type":{"default":"microsomes","description":"Assay the CLint is for; sets its units (µL/min/mg protein or µL/min/10⁶ cells).","enum":["microsomes","hepatocytes"],"title":"Assay Type","type":"string"},"fu_mic":{"description":"Unbound fraction in the incubation (0–1) the CLint would be measured at.","exclusiveMinimum":0,"maximum":1,"title":"Fu Mic","type":"number"},"fu_p":{"description":"Unbound fraction in plasma (0–1).","exclusiveMinimum":0,"maximum":1,"title":" ⟨4 unchanged words⟩ },"model":{"default":"well-stirred","description":"IVIVE liver model to invert.","enum":["well-stirred","parallel-tube"],"title" ⟨2 unchanged words⟩ string"},"rb":{"default":1,"description":"Blood-to-plasma concentration ratio; raises the plasma CL ceiling (Qh × Rb).","exclusiveMinimum":0,"maximum":50,"title":"Rb","type":"number"},"species":{"description":"Species whose liver blood flow and scaling factors apply.",
Certificate recorded, valid to 2027-01-14
Authorization not required
Unknown → Live
First tool surface recorded: 6 tools (server version 1.0.1)
https://api.ivive.app/mcp (mcp_streamable_http) — from mcp_registry, with the record
Showing the latest 6 events. The API returns up to 500 and filters by kind: ?kind=tool_surface_changed