{"$schema":"https://wellknown.network/schemas/agent-record-v1.json","schemaVersion":"1","id":"ag_dccyaa36n25q","handle":"evo2-mcp","url":"https://wellknown.network/agents/evo2-mcp","links":{"self":"https://wellknown.network/agents/evo2-mcp/record.json","html":"https://wellknown.network/agents/evo2-mcp","markdown":"https://wellknown.network/agents/evo2-mcp/record.md","api":"https://wellknown.network/api/v1/agents/evo2-mcp","status":"https://wellknown.network/api/v1/agents/evo2-mcp/status","claim":"https://wellknown.network/agents/evo2-mcp/claim","claimApi":"https://wellknown.network/api/v1/claims","claimDescriptor":"https://wellknown.network/agents/evo2-mcp/claim.json","badge":"https://wellknown.network/agents/evo2-mcp/badge.svg","openapi":"https://wellknown.network/openapi.json","history":"https://wellknown.network/api/v1/agents/evo2-mcp/history","tools":"https://wellknown.network/api/v1/agents/evo2-mcp/tools"},"ard":{"identifier":"urn:air::server:evo2-mcp","type":"application/mcp-server-card+json"},"kind":"mcp_server","declared":{"name":"evo2-mcp","summary":"MCP server for generating, scoring and embedding genomic sequences using Evo 2","description":"# evo2-mcp\n\n![evo2-mcp banner](https://raw.githubusercontent.com/not-a-feature/evo2-mcp/main/docs/_static/evo2-mcp.png)\n\n[![BioContextAI - Registry](https://img.shields.io/badge/Registry-package?style=flat&label=BioContextAI&labelColor=%23fff&color=%233555a1&link=https%3A%2F%2Fbiocontext.ai%2Fregistry)](https://biocontext.ai/registry/not-a-feature/evo2-mcp)\n[![Tests][badge-tests]][tests]\n[![Documentation][badge-docs]][documentation]\n\n[badge-tests]: https://img.shields.io/github/actions/workflow/status/not-a-feature/evo2-mcp/test.yaml?branch=main\n[badge-docs]: https://img.shields.io/readthedocs/evo2-mcp\n\nThe evo2-mcp server exposes [Evo 2](https://github.com/ArcInstitute/evo2) as a Model Context Protocol (MCP) server, providing tools for genomic sequence analysis. Any MCP-compatible client can use these tools to score, embed, and generate DNA sequences.\n\n## Features\n\n- **Sequence Scoring**: Compute log probabilities for DNA sequences\n- **Sequence Embedding**: Extract learned representations from intermediate model layers\n- **Sequence Generation**: Generate novel DNA sequences with controlled sampling\n- **Variant Effect Prediction**: Score SNP mutations for variant prioritization\n- **Multiple Model Checkpoints**: Support for 7B, 40B, and 1B parameter models\n\n## Getting Started\n\n**Prerequisites**: Python 3.12\n\n1. **Install Evo2 dependencies**: See [Installation Guide][installation] for details.\n   ```bash\n   conda install -c nvidia cuda-nvcc cuda-cudart-dev\n   conda install -c conda-forge transformer-engine-torch=2.3.0\n   pip install flash-attn==2.8.0.post2 --no-build-isolation\n   pip install evo2\n   ```\n\n2. **Install evo2-mcp**:\n   ```bash\n   pip install evo2-mcp\n   ```\n\n3. **Activate MCP Server**:\n   Add the following to your `mcp.json` configuration:\n\n   ```json\n   {\n   \"mcpServers\": {\n      \"evo2-mcp\": {\n         \"command\": \"python\",\n         \"args\": [\"-m\", \"evo2_mcp.main\"]\n      }\n   }\n   }\n   ```\n\nFor detailed installation instructions, see the [Installation Gui…","publisher":{"name":"Jules Kreuer","url":null},"homepage":"https://evo2-mcp.readthedocs.io/","repository":"https://github.com/not-a-feature/evo2-mcp/issues","version":"0.2.3","license":"GNU LESSER GENERAL PUBLIC LICENSE\n                             …","protocols":["mcp"],"tags":["bioinformatics","deep-learning","embeddings","evo2","genomics","mcp","model-context-protocol","sequence-generation"],"pricing":null,"endpoints":[{"url":"pypi:evo2-mcp","type":"package_pypi","auth":null,"probeable":false}],"skills":null,"tools":null,"extra":null,"attribution":{"kind":"pypi","name":"pypi","license":"pypi","repoUrl":"pypi","summary":"pypi","version":"pypi","description":"pypi","homepageUrl":"pypi","publisherName":"pypi"}},"derived":{"capabilities":[{"slug":"data.vector-search","name":"Vector Search","confidence":1,"provenance":"declared"},{"slug":"dev.package-management","name":"Packages & Dependencies","confidence":0.859,"provenance":"derived"}],"categories":["data","dev"],"language":"en"},"observed":{"status":"unknown","statusReason":"Distributed as a package to run locally; no network endpoint to check.","lastOkAt":null,"lastProbedAt":null,"statusComputedAt":null,"reliability30d":null,"latestObservations":[],"tools":null,"package":{"name":"evo2-mcp","registry":"pypi","observedAt":"2026-09-15T14:26:59.470Z","publishedAt":"2026-04-13T12:36:34.818918Z","latestVersion":"0.2.3"},"toolSurface":null,"endpointFacts":[]},"verification":{"claimed":false,"claimedAt":null,"proofs":[]},"provenance":{"sources":[{"source":"pypi","key":"evo2-mcp","url":"https://pypi.org/project/evo2-mcp/","firstSeenAt":"2026-09-09T15:21:58.887Z","fetchedAt":"2026-09-15T14:25:06.116Z","normalizedAt":"2026-09-15T14:25:06.116Z"}]},"firstSeenAt":"2026-09-09T15:21:58.887Z","updatedAt":"2026-09-15T14:26:59.470Z"}